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Professor of Psychology
Education
M.A., Psychology, University of Missouri at Kansas City
Ph.D., Psychology, University of Kansas
Teaching Responsibilities
Professor of Psychology, MidAmerica Nazarene Univ., 2001-current
Courses taught:
Psychopharmacology
Research Design
Applied Research
Psychopharmacology
Cognitive Neuropsychology
History & Systems of Design
Physiological Psychology
Fellow, NIH sponsored Center of Excellence in Parkinson’s Research, Univ. of Kentucky, 2001-current
Assoc Research Professor, Univ of Kansas, Dept. of Chemistry, 1989-2001
Adjunct professor, MidAmerica Nazarene University, 1987-2001
Assist. Scientist, Univ. of Kansas, Dept. of Chemistry, 1983-1988
Lecturer, Menninger School of Psychiatry, 1980-1985
Research Assoc., Univ of Kansas, Dept. of Chemistry, 1979-1983
Interdisciplinary Fellow, Menninger School of Psychiatry, 1977-1979
Research & Other Professional Interests/Activities
· Dopamine distribution patterns in human basal ganglian: Traditional understanding of the dopamine distribution patterns in the human basal ganglian has been evaluated by indirect tracing methods utilizing an enzyme that has been directly linked to dopamine neurons. This tracing method has revealed a pattern that is substantially different than that seen when direct measurements of dopamine is assessed. Direct measurement patterns are of consequence when application of neurotrophic growth hormones are utilized for treatment in Parkinson’s disease.
· Out-of-bounds dopamine in schizophrenic brains: In the last 50 yrs., the most efficacious treatment for schizophrenia is any drug that blocks a dopamine (D2) receptor. This treatment suggests an overactive dopamine system in the brain of schizophrenic patients. While this hypothesis still remains valid, little direct support for it has been scientifically derived. When areas surrounding the target locations for dopamine are analyzed, values are much higher in brains from schizophrenic patients than in normal controls. Dopamine may not have received the final proper pruning all developing brains receive when connections are completed or dopamine may simply have spread its arborizations out-of-bounds in the schizophrenic brain.
· Prefrontal brain activities in rat brain: A highly developed prefrontal cortex is seen only in the human brain.
Functionalities associated with it can only be assessed by non-invasive methods which measure vascular changes. More specific understandings of regional chemical or electrophysiological influences in the prefrontal areas can be accomplished in the non-human primate brain, which is very expensive and few laboratories have necessaries facilities for housing. It is of great interest, then, that the rodent brain become a viable candidate for prefrontal lobe functioning. Working memory, a prefrontal lobe function in human and non-human brains is being investigated in the rodent brain.
Professional Memberships & Affiliations
Member, Society for Neuroscience
Member, International Organization of Psychophysiology
Selected Publications/Presentations & Awards
Oke, A.F., Solnick, J., & Adams, R.N., Catecholamine distribution patterns in rat thalamus. Brain Res., 1988, 269, 180-183.
Oke, A.F., May, L., & Adams, R.N., Ascorbic acid distribution patterns in human brains: A comparison with nonhuman mammalian species. Ann. N.Y. Acad. Sci., 1990, 498, 1-12.
Oke, A.F., & Adams, R.N., Elevated thalamic dopamine: Possible link to sensory dysfunctions in schizophrenia? Schiz. Bull., 1992, 13, 589-604.
Oke, A.F., Adams, R.N., Winblad, B., & Von Knorring,L., Elevated dopamine/norepinephrine ratios in thalami of schizophrenic brains. Biol. Psychiat., 1993, 24, 79-82.
Oke, A.F., Is another loop needed to explain schizophrenia? Behav. Brain Sci., 1995, 14, 69-71.
Oke, A.F., Adams, R.N., & Bird, E.D., Neuroleptic treatment is an unlikely cause of elevated dopamine in thalamus of schizophrenic subjects. Psych. Res., 1996, 45, 203-208.
Oke, A.F., Carver, L.A., & Adams, R.N., Dopamine-initiated disturbances of thalamic information processing in schizophrenia? In: Schizophrenia: Origins, Processes, Treatment & Outcome, Cromwell R. & Snyder, C. eds. Oxford Univ. Press, 1997, pp. 31-47.
Oke, A.F., Carver, L.A., Gouvion, C.M., & Adams, R.N., Three-dimensional mapping of norepinephrine and serotonin in human thalamus. Brain Fes., 2000, 763, 69-78.
Contact Information
Arvin Oke
2030 E. College Way
Metz 226
Olathe, KS 66062
(913)971-3616
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